![]() A laugh like clapboards being ripped off the side of a house -Peter De Vries.Laugh … like a thrush singing -Oscar Wilde.Laugh … like a spoon tinkling against a medicine glass -Katherine Mansfield.This simile from As You Like It crops up in many a modern short story and novel. Laugh like a hyena -William Shakespeare.Laugh … like a bird’s carol on the sunrise breeze -John Greenleaf Whittier.Laugh … like the barking of a fox -Erich Maria Remarque.A laugh is just like sunshine -Anon rhyme.Laughing, a sound like wind in the grass -T. ![]() A laugh exploded out of me like a sneeze -Scott Spencer.Laughed … like the trill of a hedge-warbler -Frank Swinnerton.Laughed like a windup machine -John D.Laughed, like a bowlful of jelly -Clement C.Laughed contemptuously like a whore being offered too little money -Gary Hart.Laughed, a little drugged giggle, like chatter -Paul Theroux.(Louisa’s) laugh begins high and descends from there like a cascade -Daphne Merkin.Laugh … as if a demon within him were exulting with gloating scorn -Iris Murdoch.A horrifying derisive laugh, like rolling tin -Barry Hannah.A hoarse, very small laugh, like a cat’s cough -Frank Swinnerton.His laughter thickened like a droning bell -James Wright.A high laugh like a wicked witch -Carolyn Chute.High laugh, like a dove cry -Eudora Welty.Her laughter was a titanic, passionate thing that seemed to pass up like a wave from her toes to her mouth -Pat Conroy.Her laughter hung in the air like sleigh bells on a winter night -Jay Parini.Her laugh rang like the jangling of bracelets -Derek Walcott.Her laugh pealed out like a raven escaping into the night -Donald McCaig.Her laugh crackled … like a leap of electricity -Richard Francis.Her laugh broke like a dish -Cynthia Ozick.Her braying laugh rang out like the report of a shotgun -James Thurber.Heavy, melodious laughter, like silver coins shaking in a bag -Aharon Megged.A good laugh is sunshine in a house -William Makepeace Thackeray.Giggle, like a child watching a Hollywood adventure film -Nadine Gordimer.And) giggled like cartoon mice -Tom Robbins Giggled … like a naughty child which has unintentionally succeeded in amusing the grown-ups -Christopher Isherwood.Dry laughter like the cackle of crows or the crackling of fallen leaves underfoot -Margaret Laurence.A dry crackle like leaves crushed underfoot -Louise Erdrich.Contralto laughter, like a violin obligato under trills of a flute -Carlos Baker.Chuckling like a jovial insurance salesman -James Crumley.Chuckles … empty and round, like bubbles -Dan Jacobson.Chuckle … it sounded like a trapped wasp -Jonathan Gash.Basically when you laugh you have to make a fool of yourself … it’s like sex -Robin Williams, “Sixty Minutes” interview, September 21, 1986.As the crackling of thorns under a pot, so is the laughter of a fool - The Holy Bible/Ecclesiastes.Invasive tumor in the frontal lobe involving the prefrontal cortex and subcortical structure may cause pathological laughter, and can be cured by surgery. The pathological laughter and hemiparesis resolved within 2 weeks after surgery. The histological diagnosis was glioblastoma multiforme. Functional MR imaging showed the tumor located mainly in the prefrontal area with the posterior limit involving the premotor cortex. The hypothalamus, thalamus, internal capsule, brainstem, and cerebellum were unaffected. Cerebral magnetic resonance (MR) imaging revealed a 2.5 x 2.5 x 3 cm ring-enhanced mass in the subcortical area of the right frontal lobe associated with extensive perifocal brain edema. Her personal and social behavior was entirely appropriate except for the outbursts of laughter. The episodes of pathological laughter had become more frequent during the 3 months since the onset of hemiparesis, were elicited by non-specific, trivial stimuli, and lasted for a few minutes until she gained some control. Her face was symmetrical with intact emotional expression. Neurological examination found moderate left hemiparesis. She had no history of traumatic brain injury, or neurological or psychiatric disease, and showed no signs of drug or alcohol abuse. A 60-year-old, right-handed female presented with episodes of pathological laughter and left hemiparesis.
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